To the Editor We thank Grassi for providing his opinion regarding findings from the Diabetic Retinopathy Clinical Research (DRCR) Retina Network’s randomized clinical trial Protocol V. We agree that understanding how to prevent vision loss in patients with center-involved diabetic macular edema (CI-DME) is clinically relevant and important. We would like to comment not on the opinions he provides but point out that his arguments for routine anti–vascular endothelial growth factor (anti-VEGF) injections in patients with good visual acuity despite CI-DME may not be substantiated by the results from Protocol V.

This randomized clinical trial evaluates whether treatment with intravitreal aflibercept vs sham injections results in anatomic improvement from baseline through 100 weeks in eyes with moderately severe to severe nonproliferative diabetic retinopathy and no diabetic macular edema.

Guidance on the treatment of amblyopia has benefited substantially from outcomes obtained from randomized clinical trials (RCTs). Most RCTs on amblyopia treatment have been conducted by the National Eye Institute–supported Pediatric Eye Disease Investigator Group (PEDIG). The PEDIG public website shows the breadth of amblyopia research reported by that group and provides a key resource not only for guiding amblyopia eye care professionals, but also for instructing the design, conduct, and interpretation of contemporary clinical research on amblyopia treatment.

To the Editor We read with interest the article by Casagrande et al on the detection of SARS-CoV-2 RNA on corneas of donors with COVID-19. The authors commented that the risk of SARS-CoV-2 transmission from a donor with COVID-19 was likely to be lower in endothelial keratoplasty than in penetrating keratoplasty. However, they did not provide data on the prevalence of SARS-CoV-2 on the corneal epithelium vs on the endothelium. It would be helpful if the authors can provide the readers with such data. We have reservations regarding the claim that endothelial keratoplasty is likely to have a lower risk of transmission for the following reasons.